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Core Facilities


Advanced Bioinformatics and Bio-Computation (ABBC) Core

The Advanced Bioinformatics and Bio-Computation (ABBC) Core, formerly the Bioinformatics Research Collaboratory (BIRC), provides consultative and collaborative services, analysis, support and design for high-throughput “omics” projects, such as next generation sequencing, microarrays, proteomics, etc. and clinical trial informatics. ABBC also offers custom web-based database development for basic science and clinical projects. The goal is to provide in-house bioinformatics expertise and support for the Northwestern University clinical and translational research community, especially for Feinberg researchers, in order to produce studies that ultimately result in publications and grants. For more information on this facility click here.

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Analytical BioNanoTechnology Equipment Core (ANTEC)

Analytical BioNanoTechnology Equipment Core (ANTEC) houses research equipment for the evaluation of materials and biological preparations in the bionanotechnology laboratory.  The core primarily serves Northwestern University researchers, and is open for visiting scientists and local industry researchers. Some of the ANTEC equipment is unique to Chicago campus, including: Zetasizer Nano ZSP for zeta potential measurements, molecular weight determination, and advanced characterization of proteins, polymers, and other macromolecules; a state-of-the-art Cytation3 Automated Imager and Multimodal Plate Reader for fluorescence, luminescence, absorption assays and automatic cell imaging; two FreeZone 6 lyophilizers for freeze drying of biological and synthetic materials, a SpectraMax M5 Microplate Reader, a real-time IQ5 PCR detection system, a Kodak gel imaging system, and a refrigerated centrifuge.  NanoSight NS300 with a fluorescence detection capability for nanoparticle characterization, will be located in the J-Wing of Evanston Tech building.

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Behavioral Intervention Technology Development Core

The Behavioral Intervention Technology Development Core (BIT Core) is a part of the Center for Behavioral Intervention Technologies (CBITs; http://cbits.northwestern.edu).  BIT Core supports researchers in the conceptualization, creation and deployment of behavioral intervention technologies. Our team of technologists, psychologists, and health researchers can help you build and deploy web-based, mobile phone, tablet, and sensor-based behavioral interventions. This includes assisting in the early planning and design of the interventions, programming the interventions, and early alpha testing to ensure technical reliability.  

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Behavioral Phenotyping Core Facility

The Behavioral Phenotyping Core (BPC) helps investigators examine their mice and rats for changes in behavior. BPC's mission is to make available to funded research projects a facility to determine the behavioral effects of genetic manipulations, potential pharmaceuticals, aging, and other manipulations upon normal behavior, and the learning and memory capacities of rodents used as model systems. We can also work with PIs needing to gather pilot data. For more information about this facility, click here. Individuals wishing to use the BPC are encouraged to contact Dr. Craig Weiss during the design stage of the project.  The selection of animal strain, age and gender should be considered carefully.  Contact Dr. Weiss to discuss  selections.  For a discussion of gender differences affecting research with humans see: http://www.womenshealth.northwestern.edu/research

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Biological Imaging Facility

The Biological Imaging Facility (BIF) is a shared-use research and training resource available to all NU researchers. BIF is organized so users can prepare samples, capture and analyze images, and create final presentations in one facility. Training for all instruments is available on a regular basis so users can acquire data quickly and efficiently. We are continuously looking for new ways to enhance existing equipment, acquire new tools, and keep pace with current techniques. For more information about this facility, click here.

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Biological NMR Center

This facility is now a part of IMSERC. Please contact IMSERC to access this instrumentation.

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Biostatistics Collaboration Center

The Biostatistics Collaboration Center provides statistical support and expert consultation for the planning, design, development and execution of studies, and the analysis and interpretation of data, as well as the preparation of reports and manuscripts for basic science, clinical and epidemiologic research projects. For more information about this facility, click here.

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Biostatistics Core Facility

The Biostatistics Core Facility provides biostatistical and data management support including such services as: data analysis, clinical trial design, database design and management, design and analysis of clustered data, diagnostic screening tests, protocol preparation, and sample size determination. For more information on this facility click here.

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CCM Rodent (Preclinical) Technical Services Unit

The Northwestern University's Rodent (Preclinical) Technical Services Unit (RTSU) within the Center for Comparative Medicine (CCM) was created to advance the research and medical mission of Northwestern University.  The RTSU is committed to providing the animal biomedical research community with high quality technical expertise to support research projects. This unit serves investigators on the Chicago and Evanston campus. The RTSU professional service group is comprised of CCM team members who have had constant training and retraining under the supervision of the CCM Training and Assurance Unit.  Our goal is to apply GLP-like standards in conducting the research.

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Center for Advanced Microscopy (Cell Imaging Facility and Nikon Imaging Center)

The Center for Advanced Microscopy (CAM) at Northwestern offers state-of-the art instrumentation and services for the study of biological processes at the whole animal, tissue, cellular and subcellular levels. The facility's basic services include electron microscopy, super resolution microscopy (SIM & STORM), fluorescent laser scanning and spinning disk microscopy, fluorescent lifetime imaging, fluorescence correlation spectroscopy microscopy, automated high throughput tissue cytometry, laser capture microdissection, mutliphoton imaging, and whole animal bioluminescent and fluorescent imaging. Additionally we provide microinjection equipment, chambers for stable live cell observation, and anesthesia equipment. CAM staff members provide training on numerous different instrument platforms, consultation on experiment design, as well as digital image processing and image analysis. We are a reference site for several companies including TissueGnostics and ISS (developer of the ISS ALBA). CAM is one of three Nikon Imaging Centers in the US, allowing us access and excellent support from Nikon to develop innovative solutions for the cutting edge imaging needs of users. This relationship has allowed our users to push super-resolution technologies to permit multi-color, 3D and live-cell applications. Additionally, we have been working together with Nikon to add confocal laser scanning to a low magnification upright dissection microscope, which is particularly useful to researchers interested in visualizing thick samples (such as epidermal raft cultures) at increased cellular resolution. We are also currently expanding our full service electron microscopy offerings. Recently, we obtained a Leica Freeze Substitution Unit for TEM sample preparation allowing for improved sample quality and streamlined work-flow. Please feel free to contact us with questions.

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Center for Advanced Molecular Imaging

The Center for Advanced Molecular Imaging (CAMI) provides access to imaging modalities ranging from the nanometer scale to whole animal imaging. These include MRI, nuclear imaging (PET, SPECT, and CT), in vivo bioluminescence and fluorescence imaging, animal housing and prep spaces, and tissue culture.  Image analysis services are available, as are software packages (JIM, Amira, Matlab) and a workstation for users to perform their own data analysis.  Imaging services can be provided for investigators' own animal models, or animal models can be supplied by the Developmental Therapeutics Core. CAMI also houses a 2 photon confocal microscope operated by QBIC and atomic force microscopes operated by NIFTI. For more information about this facility, click here

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Center for Translational Imaging

Formally the Center for Advanced Magnetic Imaging (CAMRI). The Center for Translational Imaging (CTI) is the Department of Radiology's MRI research facility that is capable of high-end human and animal MR imaging. CTI has the infrastructure and staff to support all types of imaging research studies. For more information about this facility, click here.

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Central Laboratory for Materials Mechanical Properties

The Central Laboratory for Materials Mechanical Properties (CLaMMP) contains testing machines and accessories for conducting educational, research, and outreach experiments on most solid materials. The lab is available for use for both the Northwestern community and non-Northwestern researchers on an hourly-fee basis. The facility provides testing equipment for studying the mechanical behavior of materials. For more information about this facility, click here.

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ChemCore: Medicinal and Synthetic Chemistry Core

The Medicinal and Synthetic Chemistry Core (ChemCore) provides synthetic chemistry, medicinal chemistry and computational chemistry and molecular modeling services. ChemCore also provides instrumentation for compound purification and characterization. For more information about this facility, click here.

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Clean Catalysis Core

The Clean Catalysis (CleanCat) Core Facility at Northwestern University is dedicated to aiding investigators and students in the advancement of understanding the catalytic function of materials for environmental and energy processes. Supported by the Center for Catalysis and Surface Science (CCSS), the CleanCat lab is a new core facility and perhaps the first of its kind in the United States dedicated to heterogeneous catalysis. Since its inception, the facility has quickly expanded from a single lab with a reactor system to several labs containing multiple catalyst characterization tools. Our principal mission: We not only train the students to use our equipment, we teach the students how to collect data that answers their research questions. For more information about this facility, click here.  For more details about our services and rates, see the brochure below:/sites/facilities/files/ckfinder/userfiles/files/CleanCat_Brochure_v02.pdf

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Clinical Research Office-RHLCCC

The RHLCCC Clinical Research Office (CRO) provides a centralized resource to facilitate the development, conduct, quality assurance monitoring, compliance with regulatory agency requirements, and evaluation of clinical research/trials at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. As such, the office coordinates the majority of clinical research conducted in medical oncology, malignant hematology, gynecologic-oncology, neuro-oncology, radiation oncology, surgical oncology, and chemoprevention. 

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Comprehensive Metabolic Core

The mission of the Comprehensive Metabolic Core is to advance research in diabetes, obesity, and cardiovascular disease by establishing validated high-throughput hormone analyses and to create a consolidated reference center for efficient testing for the community. For more information about this core, click here.

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Computation, Modeling & Bioinformatics Center

The Computation, Modeling & Bioinformatics Center (CMBC) provides state-of-the-art analytical support to science and engineering faculty across multiple schools and departments. This support includes, but is not limited to: (a) assisting faculty in the development of new computational methods for analyzing large data sets, (b) development of methods for interfacing instrumentation with computational models for data visualization, and (c) assisting research programs in the development of rigorous approaches to modeling highly complex systems that include quantum mechanical, statistical mechanics and other molecular modeling techniques. The technical expertise, scientific knowledge, and research experience of the Director and staff provide the level of support required to address the specific needs of the scientific research community. This facility is used by a wide variety of NIH- and NSF-funded biomedical research groups in areas ranging from molecular modeling of cell membranes and polynucleotides; the analysis and storage of large amount of genomic data and the processing; and modeling and visualization of imaging data. The services provided by the Center have a direct bearing on research ranging from fundamental understanding of biological processes to the early detection of cancer through the modeling of light-tissue interactions.

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CryoEM Facility

The purpose of this facility is to provide the NU community and other institutions/entities primarily in the greater Chicago area with access to one of the fastest developing, cutting-edge imaging techniques for exploration of the structures of biological macromolecules and soft materials where applicable.  The unique strength of electron microscopy, particularly for biological applications, is its versatility.  In fact, EM is the only structural tool capable of providing structural information from a histological/cellular scale to near atomic Moreover, the range of (cryo)EM applications make it the only structural method that stands a chance to address what rapidly becomes the largest challenge in structural biology: structural genomics of interactions that represent an important pillar of systems biology.     In pursuit of its overall goal the major focus of the facility will be on providing extensive 1:1 training to potential users, and to provide support ranging from specimen development, specimen preparation, and imaging to computational image analysis, and structure determination.  For more information on this facility click here.  

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This facility provides liquid helium and liquid nitrogen to researchers and laboratories at Northwestern. For more information about this facility, click here

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Developmental Therapeutics Core

The Developmental Therapeutics Core (DTC), under the umbrella of the Center for Developmental Therapeutics (CDT), provides services focused on supporting the translation of new therapeutics to the clinic. The DTC supports grant applications and can act as an already established translational Core on multi-investigator U and P type grants. In addition to supporting basic research leading to drug translation, the DTC also provides support to clinical investigators interested in advancing new compounds into clinical trials including drug assessment and clinical protocol support. For more information on this facility click here.

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DuPont, Northwestern, Dow Collaborative Access Team

DuPont, Northwestern, Dow Collaborative Access Team (DND-CAT) has formulated a broad research program which takes advantage of 3rd generation synchrotron radiation sources. Although many fields of materials science and engineering are represented in this research program, the scientific thrust is concentrated in two main areas: study of two dimensional or quasi-two dimensional atomic structures (surfaces, interfaces and thin films), and polymer science and technology. For more information on this facility click here.

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Electron Probe Instrumentation Center

The Electron Probe Instrumentation Center (EPIC) facility offers a wide range of electron microscopy (both transmission and scanning), accessory instrumentation, and expertise to the scientific and engineering community through education, collaboration, and service. The laboratory provides facilities for the preparation and examination of many types of bulk and thin specimens (foils/films), fine particles, and replicas, including biological materials, by transmission and scanning electron microscopy. Collectively, the Electron Probe Instrumentation Center (EPIC) offers instrumentation, techniques, and expertise for all aspects of microstructure materials. Detailed information about surface morphology, size and shape analysis, local chemistry, crystallography, and texture can be obtained with the scanning electron microscopes (SEM). The SEM facility has five SEMs with digital image acquisition, including three equipped with field emission gun (FEG), and several have EDS systems. The transmission electron microscopes (TEM) allow researchers to probe the crystal structure, defects, local chemistry, electronic structure, and related information at the nanometer or less length scale. The TEM facility currently has four TEMs, including Scanning Transmission Electorn Microscopy (STEM) capabilities. The Hitachi HD2300 STEM is configured with a unique dual EDS system for ultrahigh collection angle EDS, The in-situ S/TEM HT7700 comes with a set of special specimen holders for in-situ experiments. The JEOL JEM2100F FEG TEM/STEM has sub 0.2nm probe capability, equipped with high-angle annular dark field (HAADF) detector, which gives atomic resolution of Z-contrast imaging of STEM. Three of the microscopes are equipped with Liquid Nitrogen cryo stages for biological sample observations.  The BioCryo facility of EPIC provides researchers with access to cryo electron microscopy and to an array of electron-probe based imaging and microanalytical methods. Techniques include SE-, TE-, and Z-contrast imaging, electron diffraction, Energy Dispersive X-ray Spectroscopy (EDS), and Electron Energy Loss Spectroscopy (EELS).  Both SEM and TEM facilities are equipped with specialized specimen stages for dynamic studies involving deformation, fracture, current transport, applied electrical and magnetic fields, and temperature variation from -184 ° C to 1000 ° C. The diversity and quality of SEM and TEM instrumentation, along with the numerous analytical accessories, makes EPIC one of the most advanced laboratories in the country.  The BioCryo facility offers expertise and support for planning and conducting cryo and conventional electron microscopy studies on biological samples (e.g. suspensions of molecules and particles, cells and tissues), as well as on nanoparticles, polymers, hydrogels, and other materials. Researchers can be trained to become independent users of our instrumentation and techniques. For more information on this facility, click here.

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Electronics and Laser Systems Core Facility

The Electronics and Laser Systems Core (ELSC) Facility provides instrumentation and electronics support to the Department of Chemistry and the greater Northwestern University community. The ELSC can perform electronics design, systems automation and integration, instrumentation repair and general consulting when evaluating new instrumentation.

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Flow Cytometry Core Facility - Cancer Center

The recognition of the complexity of flow cytometric analysis has caused many journals and granting organizations to scrutinize flow data. Thus the core flow lab is becoming an important research resource as well as service provider and a prudent investment for academic institutions. The challenge for the academic core facility is to meet both the scientific and technical mission by providing high quality services in a cost-effective and timely manner. Serving 175+ investigators on the Chicago and Evanston Campuses, with 3 sorters and 6 benchtop analyzers with 16+ color capabilities, we have developed a paradigm to balance productivity with quality to minimize the cost per research project, keep overall costs contained, and provide the necessary scientific support. Central to this paradigm is a close working relationship with investigators to define their projects in the early stages of development to make optimal and efficient use of flow cytometry..For more information about this facility, click here.

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Genomics Core Facility

The Genomics Core Facility at the Center for Genetic Medicine is a shared resource facility that provides a wide range of services to Cancer Center members and the Northwestern University research community. Our goal is to provide services using the state-of-the-art technologies at an affordable price. The Genomics Core Facility offers a multitude of genomic services, including next generation sequencing using our SOLiD5500xl System from Applied Biosystems and the new Ion Torrent system, a range of traditional sequencing and fragment analysis options using our ABI 3730 high-throughput sequencer, microarray analysis for gene expression, methylation and SNP studies using Affymetrix technology and the Illumina iScan system, and validation of methylation and SNP analyses using the Sequenom MassARRAY4 system. For more information about this facility, click here.  

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High Resolution Electron Microscopy and Surface Structure Facility

The High Resolution Electron Microscopy and Surface Structure Facility provides unique equipment to investigate the atomic scale structure of both the surface and subsurface region of a sample combined with in-situ growth, gas treatment and chemical characterization.

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High Throughput Analysis Laboratory

The High Throughput Analysis Laboratory (HTAL) provides academic, industrial, and private researchers with equipment and expertise for the development and execution of high throughput biological analysis and screening. The facility is fully equipped with state-of-the-art liquid handling, plate detection and automated microbial culture handling capabilities. For more information about this facility, click here.

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Immune Monitoring Core

Sequential monitoring of the human immune system by studying the peripheral blood and even bone marrow and allograft (biopsy) compartments in tissue and organ transplantation had its origins in the 1970s. Ex vivo assays of T, B, NK and APC function have become much more sophisticated today and  include the detection and definition of unique cell subsets and intra- and extra- cellular molecules. Their defined function and inter-relationships in human organ and tissue transplantation requires the use of technology based on in vitro immune cell assays, molecular  immunoassays, proteomics,  genomics and even humanized mouse models, i.e. cellular and molecular immunology that is in continuous evolution. For each of these investigative paths expertise has become more specialized needing dedicated faculty, pre- and post-doctoral fellows and technologists, as well as instrumentation and dedicated work space.

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Instrument Shop - Evanston

The Northwestern University Instrument Shop is a full service machining, fabrication and repair facility capable of meeting the needs of an active research community. We support researchers in the physical and life sciences. The Shop is staffed by four highly talented instrument makers with over 150 years experience. The Shop is a fully equipped machine shop outfitted with manual and CNC (computerized numerical control) machines. For more information about this facility, click here.

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Integrated Molecular Structure Education and Research Center

The Integrated Molecular Structure Education and Research Center (IMSERC) facility performs a full range of chemical analyses. Such analyses include qualitative composition determination, quantitative analysis, and molecular structure determination.  The most commonly used techniques are NMR spectroscopy, mass spectrometry, optical spectroscopy, trace metals analysis and single crystal X-Ray crystallography. For more information about this facility, click here.

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Jerome B. Cohen X-ray Diffraction Facility

The primary function is to provide general-purpose x-ray equipment for scattering and fluorescence studies. The facility can also provide equipment for non-routine experiments such as, special attachments for high temperatures, vacuum or protective atmospheres, monochromators, special linear and area detectors, etc. Examples of current measurements are: powder diffraction (XRD), single-crystal diffraction, thin-film reflectivity (XRR), thin-film diffraction, crystal truncation rod scattering (CTR), small angle scattering (SAXS), Laue diffraction, pole figures, energy dispersive X-ray Fluorescence spectroscopy, x-ray standing waves, high-resolution x-ray diffraction (HRXRD), and grazing incidence wide-angle scattering (GIWAXS), and GISAXS. The X-ray lab also functions to help prepare students and postdocs for their beamtime at the Advanced Photon Source (APS).  For more information about this facility, click here. Equipment: There are presently thirteen experimental x-ray stations available, five of which have rotating anode sources. 

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Keck Biophysics Facility

The Keck Biophysics Facility provides researchers with 24-hour access to a collection of advanced instruments for biophysical and biochemical characterization of macromolecules and their interactions. Training, technical expertise and assistance are provided by the facility personnel. Staff service on selected instruments is available. For more information about this facility, click here.

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Keck Interdisciplinary Surface Science Facility (Keck-II)

The Keck-II Center was established in late 2001 through the support of W. M. Keck Foundation. Keck-II also has received some support from Northwestern's Institute for Nanotechnology's NSF-sponsored Nanoscale Science & Engineering Center (NSEC) as well as from the State of IL and Northwestern. Keck-II facilitates research, collaboration, education and outreach in all science from soft biological matter to hard physical matter, specializing in surface analysis and nano-scale characterization.  Keck-II hosts Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS), X-ray Photoelectron Spectroscopy (XPS), Fourier Transform Infrared Spectroscopy (FT-IR), Confocal Raman System, High Resolution Stylus Profilometer, 3D Optical Microscope, Spectroscopic Ellipsometer, and Zetasizer. Keck-II is open to all the faculty and students at Northwestern University as well as the researchers at the nearby academic institutions and related industrial companies. The Keck-II Center operates and functions like its sister facilities (SPID and EPIC)-based on the core philosophy of open-access, hand-on training, collaboration and assistance from our able staff. Training is offered on a periodic basis, both as “crash courses” or part of hands-on structured courses, as well as individual ad-hoc training as need arises.

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Life Sciences Collaborative Access Team

The Life Sciences Collaborative Access Team (LS-CAT) provides macromolecular cystallography resources for those with a need to determine the structure of proteins. Mainly LS-CAT provides access to state of the art x-ray diffraction facilities at Argonne National Laboratory's Advanced Photon Source where extremely intense beams of x-rays are focused using both mirrors and beryllium lenses onto tiny protein crystals. The x-rays diffracted by these crystals are collected with giant CCD detectors that produce the images needed to calculate where the atoms in the protein crystal are. For more information on this facility click here.

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Magnet, Low Temperature, and Optical Facility

This facility maintains various magnet, cryogenic and optical systems operating either separately or together. The systems are designed to be as flexible as possible, and to allow several types of measurements to be performed over a wide range in magnetic field, temperature, and probe frequencies (including both uhf/microwave and optical). The dc and uhf/microwave frequency measurements that are routinely performed include magnetization and magnetic susceptibility, acoustic propagation, microwave absorption, electrical transport (including thermoelectric measurements). Routine optical measurements include optical absorption, photoluminescence, pump-probe studies, and Raman spectroscopy.  For more information on the facility, click here.

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Mary Beth Donnelley Clinical Pharmacology Core Facility

The mission of the Mary Beth Donnelley Clinical Pharmacology Core Facility is to provide state-of-the-art clinical pharmacologic support to Northwestern University investigators as an integral part of bench-to-bedside drug development.  The Clinical Pharmacology Core provides pharmacokinetic support for preclinical and clinical studies of cancer chemotherapeutic agents, analgesics, and other small molecules.  Expertise includes optimizing the design, conduct, analysis, interpretation, and reportage of pharmacokinetic studies.  Small molecule concentrations in plasma and other body fluids are measured using an Agilent HPLC system linked to an Applied Biosystems API 3000 triple quadrupole mass spectrometer.  Drug concentration histories are fitted to various compartmental pharmacokinetic models using commercially available and specialized software. For more information about this facility, click here.

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Materials Processing & Microfabrication Facility - Cleanroom

The Materials Research Center (MRC) cleanroom facility is devoted to materials processing, growth, device fabrication, characterization and electronic & photonic  materials. The MRC cleanroom complex in Cook Hall provides microfabrication and thin film processing capabilities. Facility includes class 100 and 1000 cleanrooms. The facility provides microfabrication tools for general use by the Northwestern community, government and industrial researchers. Various techniques are available for the growth, preparation and processing of a wide range of thin film materials including in-process characterization. Training of equipment and assisted use within the facility is available to provide the necessary expertise. This provides a centralized resource for the deposition of metal, semiconductor & dielectric thin films, photolithography, and processing. Standardmicrofabricationprocesses have been established. Available techniques include plasma enhanced chemical vapor deposition, e-beam evaporation, atomic layer deposition, reactive ion etching, photolithography, bonding, rapid thermal processing, Hall Effect Measurement and some characterization instrumentation. For more information about this facility, click here.

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Mathews Center for Cellular Therapy

The Mathews Center for Cellular Therapy at Northwestern Memorial Hospital is located in downtown Chicago and is a major catalyst for implementing biologic and cellular therapies into clinical use.   The MCCT consists of regulatory compliant laboratories and services encompassing both minimally manipulated as well as complex biological products.    Four product manufacturing suites  are operated under good manufacturing practices (GMP) and can be adapted to most biologic and cellular processes for phase I through phase III clinical trials A large general laboratory that follows good laboratory practices (GLP) is utilized for minimally manipulated products Access to 24/7 monitored cryopreservation storage facilities for manufactured products; CLIA certified testing for release criteria; experienced laboratory management and staff; and regulatory and process support The MCCT at NMH provides stem cell products, culture expanded cellular products and isolated cellular subpopulation products to the adult stem cell transplant program, the solid organ transplant program and the division of allergy and immunology programs at Northwestern Memorial Hospital.  In addition, pediatric cellular products are provided for the Robert and Ann Lurie Children’s Hospital of Chicago.  The MCCT collaborates with nation-wide biotechnology companies for cellular and biological therapies. For more information on this facility, click here.  

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Microsurgery Core

The Microsurgery Core is dedicated to assisting investigators with a central resource for creating mouse and rat models of tissue and organ transplantation. It provides a valuable and unique research opportunity for translational research from animal studies to human diseases. For more information on this facility, please click here.  

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Mouse Histology and Phenotyping Laboratory

The Mouse Histology and Phenotyping Laboratory (MHPL) is designed to assist investigators with their research histology needs, as well as gross and histological characterization of genetically modified murine models. Studies can be performed on individual organs or involve a systemic overview of all major organ systems. Pathologist consultation will allow the development of strategies to elucidate the phenotype and gain mechanistic insight regarding the biologic actions of the targeted molecule. For more information about this facility, click here. MHPL Homepage

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Nanomedicine Clean Room

Simpson Querrey Institute (SQI) Nanomedicine Cleanroom Core Facility is specifically designed for interdisciplinary research at the interface of physical and biological sciences. A fully functional photolithography line is located in the class 100 room. This room houses a mask aligner/exposure system, a spin coater, hot plates, and a laminar flow fume hood. The class 10,000 room incorporates a cell culture area, complete with a tissue culture hood, two incubators, a centrifuge, and a cell culture microscope. For more information about this facility, click here.

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Next Generation Sequencing Facility

The Next Generation Sequencing (NGS) Core Facility is committed to meeting the NGS needs of researchers at Northwestern University and its affiliate institutions by facilitating NGS on diverse platforms as well as providing bioinformatics analysis. The NGS Core strives to deliver the highest quality sequencing data and bioinformatics analysis at reasonable rates. For more information about this facility, click here.

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Northwestern Medicine Enterprise Data Warehouse

The Northwestern Medicine Enterprise Data Warehouse (EDW) is a single, integrated database of all clinical and research data from all patients receiving treatment through Northwestern healthcare affiliates.Consolidating this wealth of data into a single database maximizes efficiency and centralizes security, making data available yet controlling access to assure consistency with consents and regulatory requirements. The purpose of EDW is to collect, integrate and disseminate data. The EDW serves the role of an honest broker for clinical information to the Northwestern research community. For more information about this facility, click here.

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NU Center for Atom Probe Tomography

Atom Probe Tomography (APT) produces a three-dimensional (3D) atom-by-atom image of a sample, with sub-nanometer spatial resolution and a typically 150x150x500 nm^3 analyzed volume, by simultaneous high resolution imaging and time of flight mass spectrometry. APT is particularly suited to study nano or nanostructured materials. The same samples can also be characterized by Transmission Electron Microscopy (TEM), in a correlative study. To compare these experimental results with atomistic simulations on the same size scale, ab-initio calculations and Monte-Carlo simulations can be performed at our facility. NUCAPT operates a CAMECA LEAP 4000 XSi tomograph. Specimen tips can be prepared by electropolishing (metals) and from almost any material by FIB ( Focused-ion beam milling ). Ion beam sputter deposition creates thin film structures that aid with APT specimen preparation. A small arc melter is available for syntesizing alloys and compounds. Thermocalc and MEDEA software packages are available for thermodynamic calculations and materials simulations.  For more information about this facility, click here.

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NU Transplant Outcomes Research Collaborative

NU's Transplant Outcomes Research Collaborative (NUTORC) builds upon the existing strengths of the transplant program at Northwestern and has created highly productive inter-school, multi-departmental, and trans-disciplinary collaborative initiatives. We bring together clinicians, health services and outcomes researchers, and investigators with specific expertise in state-of-the art research methodologies to address pertinent questions in transplantation. Initiated in late 2008, these initiatives have already led to collaborative grant funding through NIH, AHRQ, NSF and HRSA in addition to other funding sources.

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NUCATS-Center for Clinical Research

The Center for Clinical Research (CCR) provides resources and services for all clinical researchers, including: Budget preparation, review, and reconciliation Regulatory filings at IRB and FDA Research participant recruitment Clinical research coordinators Support for ClinicalTrials.gov Clinical Research Navigation NMH Clinical Research Unit: Space, nursing, core lab, and bionutrition support Lurie Children’s Hospital Clinical Research Unit: Space and nursing To read the Office for Research Newsletter Article on this facility, click here. Key Contacts: Center for Clinical Research 312-503-9999centerforclinicalresearch@northwestern.edu

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NUCATS-Clinical Research Unit (Lurie Children's Hospital)

The Clinical Research Unit (CRU) at Lurie Children’s is a child and family friendly environment which offers 8 outpatient private exam rooms, 6 dedicated inpatient beds and a consultation room.  Facilities available to meet the need of investigators include touchdown space for investigators and auditors/monitors, limited investigator supply and equipment storage and refrigeration of specimens.  The unit can be utilized with full nursing services, or for space only.   A clinical manager oversees the clinical research unit, which is staffed by a unit secretary and registered nurses who have been Pediatric Advanced Life Support (PALS) certified. The CRU also has a fully staffed and dedicated research pharmacy and laboratory support.   Contact:  Rena Carrizoza Project Coordinator 312-227-4011 rcarrizoza@luriechildrens.org  

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NUCATS-Clinical Research Unit (NMH)

  The CRU offers investigators physical facilities including inpatient and outpatient space, a core laboratory, as well as research nursing and research dieticians to conduct patient-oriented research.  Facilities are located in both the Feinberg and Galter Pavilions of Northwestern Memorial Hospital (NMH). If you would like to use any of the CRU services, please learn more about the CRU submission process. The CRU services and resources include: Space: Four inpatient beds in Feinberg; Five outpatient rooms in Feinberg; Three outpatient rooms in Galter Nursing Services Core Laboratory  Bionutrition

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NUFAB Cleanroom

NUFAB is an advanced micro/nano fabrication research facility at Northwestern University. It provides resources for research in MEMs/NEMs, nano-bio, nano/microelectronics, and other related and interdisciplinary areas to Northwestern University community and outside researchers. It currently resides in EG20-NG32 Tech Institute and has all new research equipment. Please check the equipment list on this site. In 2012, it will relocate to a new clean room facility at FG infill that is under construction. For more information about this facility, click here.

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NUgene is a biospecimen repository with longitudinal medical information from participating patients at Northwestern-affiliated outpatient clinics and hospitals. Participants' consent to genetic research on their DNA samples and health data. NUgene is an institutional resource providing investigators with coded DNA samples and data for genomics research, as well as a vehicle for participant recruitment and contact for secondary studies.

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Optical Microscopy & Metallography Facility

This facility is equipped for the metallographic preparation of specimens by producing strain-free surfaces usually examined by optical microscopy. Other applications of mechanically polished specimens involve producing strain-fee (surface) tensile specimens, optically flat electrodes, and flat substrates for subsequent thin-film depositions. Both transmitted light and reflected light metallographs are available for photomicrography and microstructural characterizations. For more information about this facility, click here.

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Outcomes Measurement & Survey Core

The Outcomes Measurement and Survey Core (OMSC) serves the needs of the cancer researchers within the Robert H. Lurie Comprehensive Cancer Center. The mission of this core facility is to provide consultation and support for research that involves collecting, analyzing or interpreting self-report data in culturally diverse populations. The OMSC is housed within the Department of Medical Social Sciences, which also provides similar services to any member of the Northwestern community. For more information about this facility click here.

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Pathology Core Facility

The Pathology Core Facility (PCF/PathCore), established in 1997, provides specimen analysis, procurement, processing, and banking services to facilitate basic, translational, and clinical research at Northwestern University. Its services include Histochemistry, Immunochemistry, Nucleic Acid Analysis and Extraction, and Microscopic Evaluation. PCF is Northwestern's only dually CLIA certified and College of American Pathologists (CAP) accredited facility. In 2001, PCF was designated as the ECOG-ACRIN Cancer Research Group's Pathology Coordinating Office and Reference Laboratory (PCO-RL). With this designation, it serves as the centralized center for the coordination, processing, and distribution of ECOG-ACRIN trial related biospecimens obtained from consented patients around the world. For more information on this facility click here.

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Peptide Synthesis Core

The Simpson Querrey (SQI) Peptide Synthesis Core Facility produces custom peptides for SQI members, NU researchers, and other local academic and commercial labs. Our facility provides customers with high quality peptides synthesized at 0.1-2mmol scales and purified by reverse-phase HPLC. We can also carry out side chain or terminal modifications such as the addition of fluorescent or biotin labels according to the customers' research applications. In addition, we utilize the leading-edge Agilent 6520 Q-TOF LCMS system to develop and deliver a wide range of mass spectrometry services. For more information about this facility, click here.

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Proteomics Center of Excellence

The Proteomics Center of Excellence (PCE) houses the best technology for “Top Down” Proteomics, which will push the limits for analysis of whole protein molecules. In Top Down proteomics, proteins are analyzed without digestion to get a handle on the dynamics of a whole protein.The center will implement known technologies for “Bottom Up”, but emphasize the philosophy of ‘precision proteomics,’ which uses high performance mass spectrometry to deliver protein identifications with very high confidence and in a gene-specific fashion. Quantitation of protein expression and confident assignment of post-translational modifications will also be possible in a highly collaborative framework. With our triple-quadrupole mass spectrometer, we can provide quantitative site-specific information about methylations and acetylations on histones.   Contact us: pce@northwestern.edu

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Proteomics Core

The Proteomics Core Facility manages and performs proteomics projects from the initial consultation with investigators through publication in the primary literature and inclusion in research proposals. To provide Northwestern University Researchers with the technologies needed to perform high-quality proteomics, we have acquired an LTQ Orbitrap Velos, the most advanced, commercially available ion trap instrument to support the routine operation of the facility. The LTQ Orbitrap Velos offers superior scanning speed and mass accuracy translating into more identification with higher confidence. For more information about this facility, click here.

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Quantitative Bioelemental Imaging Center

The Quantitative Bio-element Imaging Center (QBIC) provides researchers with access to state-of-the-art imaging and quantification instrumentation while supporting its use with an expert technical staff that offers a range of services, including instrument training, sample preparation and analysis, experiment design, and grant proposal assistance.  The combination of both extremely high sensitivity elemental analysis and high resolution imaging enables QBIC customers to perform cutting edge experiments with ample staff support. For more information about this facility, click here.   

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Recombinant Protein Production Core

The Recombinant Protein Production Core (rPPC) provides quality controlled recombinant proteins for researchers within the Northwestern Community (WCAS, McCormick, Feinberg) and also serves academic and industry researchers outside of Northwestern University. rPPC operates based on the two service models: (1) aTraining model where Northwestern researchers use specialized bioreactor systems and participate in hands-on-training activities and (2) a Production model where staff carry out expression (mg to gm scale) and purification of recombinant or synthetic biologics, including potential therapeutic proteins and peptides, among others. Currently, the main focus of rPPC is to be a user-facility; the facility has parallel bioreactor systems for multiplexed lab-scale cultivation of microbial, insect, and mammalian cells. rPPC also serves as a production facility, providing low-cost recombinant biologics for researchers at Northwestern University. For more information about this facility, click here.

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Scanned Probe Imaging and Development (SPID) Facility - formerly NIFTI

SPID was created to drive interdisciplinary research bridging the gap between hard nanostructures, soft materials, biological sciences, quantitative mechanical and electrical analysis and nanopatterning. SPID provides a wide range of imaging instrumentation and support facilities for atomic to molecular imaging. It supports a broad range of nanoscale science and technology characterization needs at nanoscale by providing state-of-the-art resources coupled with expert staff. Research at SPID encompasses physical and chemical sciences, engineering and life sciences, and has a strong inter-disciplinary emphasis. Every week, several new users coming from NU campuses, academia, industry, and government laboratories learn to use tools available in the center to carry out their research projects. The primary focus of SPID is to provide both quantitative and qualitative scanning probe microscopy and biomaterials nanopatterning based highly advanced instrumentations to enable materials, nanopatterning and biomedical research by a diverse group of scientists, industries and clinicians representing numerous disciplines. SPID works in partnership with several industrial partners and specifically Bruker Metrology Surface Division to develop advanced instrumentation for quantitative analysis. SPID serves as a hub for numerous global partnerships both in terms of facility development and research. For more information about this facility, click HERE

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Skin Disease Research Center

The goal of the Northwestern University SDRC is to promote outstanding bench and clinical research in cutaneous biology, ultimately to improve patient care. The SDRC is comprised of an Administrative Core and three distinct Research Cores which include the Skin Tissue Engineering Core (previously the Keratinocyte Core, the Morphology & Phenotyping Core (previously the Pathology Core) and the DNA/RNA Delivery Core. These core facilities are designed to help SDRC investigators accomplish their research goals related to cutaneous biology and to provide a level of support to newly recruited junior investigators who are interested in skin research. The Cores strive to provide all SDRC users with access to specialized techniques, expertise, biological analysis and instrumentation that enhances research progress. To read the OR Newsletter article on SDRC, click here. For additional information on this facility visit the SDRC website  here. SDRC Administrative Office: Ward #9-132, 303 E. Chicago Ave.  Admin Phone: 312-503-1815  SDRC Lab: Tarry #4-750, #4-753, 303 E. Superior St. Lab Phone: 312-503-4407

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Sleep, Circadian and Other Rhythm Experiments Core

The Sleep, Circadian and Other Rhythm Experiments (SCORE) Core's fundamental mission is to advance our understanding of rhythms in health and disease. The Core will be dedicated to supporting research of sleep, circadian, gene expression, endocrine, behavioral, and reproductive rhythms in rodent models. Equipment, experimental housing, and experienced personnel are avaialble to carry out a wide range of experimental designs. The Core will also offer training and consulting in experimental design and data analysis of rhythm studies. 

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Stem Cell Core Facility

Stem Cell Core Facility Lab at Northwestern The stem cell core facility was founded in 2009 by Dr. Jack Kessler, Ken and Ruth Davee Professor of Stem Cell Biology at the Feinberg School of Medicine. This was immediately after President Obama signed an executive order repealing a policy that limited federal tax dollars for embryonic stem (ES) cell research and the discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka. Being a long-time enthusiast of human stem cell research and one of the pioneers in the field at Northwestern University, Dr. Kessler foresaw the growing interest of basic researchers and medical doctors in this rapidly developing and highly promising research area. The mission of the stem cell core facility is to engage scientists at Northwestern University and the greater Chicago Biomedical Consortium and enable them to do stem cell-based research. The facility is currently funded by an NIH P30 grant and Feinberg School of Medicine. The facility is situated on the 10th floor of the Lurie research building (#10-232). It encompasses approximately 800 square feet of lab space that is perfectly equipped to allow for the culture of human ES and iPSCs. It offers technical support in basic culturing techniques of human ES and iPS cells, including focused training sessions; it provides lab space and equipment for researches that want to engage in stem cell-based projects; it generates iPSCs through a range of different techniques; as well as providing general consulting and support for iPSC-based disease modeling projects.  

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Structural Biology Facility

The facility is essential for the research programs of investigators who are studying the relationship between macromolecular structure and function or who are using protein structure as the starting point for structure-based drug design. The Structural Biology Facility is a unique resource at Northwestern University that capitalizes on the extensive expertise of a large group of users and regular access to the synchrotron radiation X-ray source at the LS-CAT at the Advanced Photon Source of Argonne Lab. For more information about this facility, click here.

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Surface Science Facility

The Surface Science Facility provides multiple-technique characterization of a variety of surfaces with regard to atomic structure, surface chemical composition, and chemical bonding characteristics.

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Transgenic and Targeted Mutagenesis Laboratory

The Transgenic and Targeted Mutagenesis Laboratory (TTML) is a shared resource that provides a broad range of services to NU investigators, including generation of transgenic mice, gene targeting of embryonic stem (ES) cells, ES cell microinjection into blastocysts, mouse germplasm cryopreservation, recovery of cryopreserved mouse lines, and rederivation of pathogen free mouse strains. For more information about this facility, click here.

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